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Agaricus Blazei Murill Mushrooms

Agaricus Blazei Murill mushrooms are a prominent cancer treatment in Japan.  This page shows why and gives one Japanese source.  We are actively looking for alternate sources in Brazil or elsewhere, and we insist on cheaper prices.  If you know of any, send email to me (see above menu).

 

Although the first reports of this mushroom date from the forties, only after its discovery in Brazil, in 1965, l - for Mr. Furumoto, a Japanese farmer from Piedade/SP -, a larger interest of the scientific community was aroused, mainly in Japan (country that received the first samples), United States and China. Since then, several researches have been accomplished, demonstrating the qualities and benefits of Agaricus.

In Brazil, the production of Agaricus blazei in commercial scalei just begun in 1989, when the Iwade Laboratory of Japan, signed a cultivation contract with SB Cristal (Kazumasa Abe). Finally, more than 20 years after, the mushroom was back to its homeland.

Considering the nutricional and physiologic importance of the Agaricus mushrooms, Kazumasa Abe requested in 1998, through National Biosciences and Human Technology Institute from the Industrial Technology Agency of the Ministry of International and Industrial Trade of Japan, the patenting of Agaricus blazei BM8, in the Budapeste Agreement about the International Recognition of Micrrorganism Deposit, with the number FERM BP-6480.

Agaricus in natura contains 85 to 87% of water. After the dehydration, it is rich in proteins and carbohydrates and it contains considerable amounts of vitamins - B1, B2, B3 and ergosterol, that it is transformed in D2 vitamin after exhibition to light and cooking -, lipeds (represented mainly by poli-insaturated greasy acids), minerals - potassium (about 2%), phosphorous, magnesium, calcium, sodium, copper, zinc, iron and molibdenium.

In chemical composition, besides the mentioned nutrients, we can found glycoproteins, steroids and polysaccharides complexes with proteins that, when analyzed in laboratory cavies, present properties that potentialize the immune system, the homeostasys and improve the physical conditions of the organism, besides producing pronounced antitumor activity.

Agaricus originates from Piedade, which is located in the suburbs of Sao Paulo, Brazil. The climatic conditions in Piedade include temperatures that soar to 35º during the day and dip to between 20º and 25º at night, with a humidity that averages 80 %. The place also experiences regular squall toward evening. Agaricus thrives only under these conditions, suggesting that its survival is significantly affected by these external conditions.

Some 30 years ago, a US researcher noted that the rate of occurrence of adult diseases in the Piedade region is extremely low, and found that it was because of the Agaricus that was a part of the regular diet of the inhabitants of this area.

Around the same time, Agaricus was introduced to Japan. Dr. Shoji Shibata, who at the time was a professor in the Pharmacological Department of Tokyo niversity, and Dr. Tetuo Ikegawa of the National Cancer Center, jointly researched the pharmacological effects of Agaricus. The research results were released at the general convention of the Japan Pharmacological Association and the Japan Cancer Association. The experience with mice verified that the polysaccharide Beta-glucan contained in Agaricus significantly activated the immune system.

As Agaricus grows only in certain conditions, its production in Brazil remained unstable. Moreover, Agaricus was mostly consumed locally, and importing it into Japan was extremely difficult. Despite efforts in Japan over many years to cultivate Agaricus under artificial conditions, it proved extremely difficult, and failed to guarantee a stable production output. However, in 1992, kyowa Engineering achieved a world first when it successfully mass-produced Agaricus by taking advantage of the company's biotechnological expertise. Consequently, the company was able to provide a stable supply of Agaricus to the health food market.

 
Dry ABM
Ingredients		 water
7.5 %		 protein
36.7 %		 fat
3.4 %		 fiber
6.8 %		 ash
7.3%		 sugar
38.3 %
phosphor
939mg/100g		 iron
18.2mg/100g		 calcium
41.6mg/100g		 vitamin B1
0.48mg/100g		 vitamin B2
2.84mg/100g		 ergosterol
354mg/100g		 niacin
40.9mg/100g


Results of Agaricus Experiments using Guinea Pigs

 

The table below shows the results of tests on anti cancer properties of Agaricus conducted on guinea pigs at the Medical Department of Tokyo University, the National Cancer Center Laboratory and Tokyo College of Pharmacy.

 
Name of fungus Daily
dosage		 Rate of complete
recovery		 Anti cancer
effect
Agaricus blazei Murill 10mmg 90.0% 99.4%
Grifola umbellate 10mmg 90.0% 98.5%
Phellinus yucatensis 30mmg 87.5% 96.5%
Phellinus igniarius 30mmg 66.7% 87.4%
Lenzites betulina 30mmg 57.1% 70.2%
Tricholoma matsutake 30mmg 55.5% 91.3%
Lentinus edodes 30mmg 54.5% 80.7%
Coriolus versicolor 30mmg 50.0% 77.5%
Pleurotus osteatus 30mmg 45.5% 75.3%
Elfringia applanata 30mmg 45.5% 64.9%
Fomitopsis pincicola 30mmg 33.3% 61.2%
Fomitopsis cytisna 30mmg 30.3% 44.2%
Pholiota nameko 30mmg 30.0% 86.5%
Flammulina velutipes 30mmg 30.0% 81.1%
Ganoderma Lucidum 30mmg 20.0% 77.8%

 

The table shows that agaricus blazei Murill produced high results for both a complete recovery and for its anti cancer effect. The experiment used guinea pigs of between five and six weeks old, which is equivalent to 15 and 16 years old in human terms.

Vaccinating sarcoma 180 (a type of cancer cell) into the femur of these guinea pigs normally causes cancer to spread to the entire body over four to five weeks, resulting in the death of almost all these animals. The fungus extract was first administered 24 hour later when the cancer cells were firmly embedded in the animals tissues, and the process continued for 10 consecutive days. The results were then recorded four to five weeks later. The experiment was repeated on groups of between five and ten Guinea pigs, which were each given a different fungus extract. The mean values taken from these experiments were expressed as percentages.

The anti cancer effect rate represents the percentage of guinea pigs which fully recovered from the cancer induced by an initial vaccination of sarcoma 180 and in whom a second vaccination of sarcoma 180 failed because the cancer cells could not be successfully embedded.

From these results, it was deduced that the fungus extract (component primarily comprising a high-molecular polysaccharide) activates the immunity of normal biological tissue, so that even when a virus or other external factors enter the tissue, macrophage and interferon production within the tissue is vitalized to prevent the multiplication, metastasis and reoccurrence of cancer cells.


The polysaccharide contained in Agaricu blazei Murill vitalizes production of interferon and interleukin in small animals (guinea pigs). This effect indirectly functions to destroy or prevent the proliferation of cancer cells. This refers to a cytokine inducing effect. Moreover, the experiments conducted by the researchers named above proved that this effect can also prevent viruses and other external factors from entering the tissue.

Clinical results obtained in collaboration with university researchers and hospitals since the report on the anti cancer effect of Agaricus blazei Murill was released at the general convention of the Japan Cancer Association in 1980 proved that although many fungi polysaccharide only effect solid cancer and polysaccharide of Agaricus blazei Murill is effective against Ehrlich*s ascites carcinoma sigmoid coloniccancer, ovarian cancer, breast cancer, lung cancer, and liver cancer as well as against solid cancer.

The results of the experiments suggest that it also activates metabolism by revitalizing nomal biological tissue.

Digestive enzymes such as amylase trypsin martase and the protease contained in fungus also enhances digestion. Furthemore, tyrosinase,an enzyme which oxydizes tyrosine and produces melanin, has a hypotensive effect.

It was only recently that melanin protein - which is effective in the production of semen, hair and egg white - was discovered in Agaricus blazei Murill.

 
Examples of Gastronomic Effect and Treatment Researched Elements
Anti tumor effect (Sarcoma 180/mice, ip method)
Agaricus blazei Murill activates macrophage, immunocytes such as complements retculoendothelial system, acts to induce cytokine such as interferon as well as BRM, and prolongs the biological life through its immunological effects.		 Polysaccharides
Beta- D-glucan, Beta- D-glucan protein compounds, acid heteroglucan, Xyloglucan, heteroglucan protein compounds, RAN protein compounds glycoprotein (lectin), etc.
Cancer prevention effect
Effect of absorbing and discharging cancerous materials		 Dietary fiber
Non digestive Beta-glucan, heteropolysaccharide, chitin
Reducing blood glucose Polysaccharide (Beta-glucan)
Polysaccharide protein compounds, RNA compounds
Hypotensive effect, reducing cholesterol, reducing arteriosclerosis Dietary fiber and unsaturated fatty acid such as linolic acid composing lipid
The Chemical Times,ISSN 0285-2446
Kanto Chemical Co., inc., 1989, No.1(131 Volumes in all) extract from P.12.P21 Takashi Mizuno: Phamacological and Gastronomic Effects of Fungi and its Applications

Immunity and Agaricus blazei Murill

Living organisms are equipped with immunity system which expels pathogens, toxic chemicals and tumorous cells generated through mutation. When tumorous cells attach to form a simple protein lump, it is decomposed by microorganisms such as bacteria. Thanks to this function, which is called immunity, bodies can maintain their health by fighting off harmful microorganisms, stopping them from entering tissue or discharging them from tissue.

When their immune systems work properly, humans remain healthy. However, the immune systems in many people are weakened by stress, poor eating habits and pollution, such as air pollution. These people can suffer from a number of diseases.

It is widely believed that cancer is caused by a decline in the immune system caused by aging and other factors. It is also known that atopic dermatitis asthma, pollinosis and rheumatism result from an excessive immuno reaction. The AIDS virus destroys immuno cells and triggers diseases.

To keep the immune system functioning properly, it is vital to follow the practices listed below:

  • Do not allow yourself to be overcome with stress.
  • Avoid fatigue and get enough sleep.
  • Do not smoke or drink excessively.
  • Maintain a balanced diet.
  • Take moderate exercise.

However, adopting all of these habits can be quite difficult.

Agaricus blazei Murill, which is enjoying growing attention, contains a large amount of polysaccharide, which is believed to enhance immunity. It does not only bolster immunity but reduces excessive immuno reactions to maintain a balance. Of all fungi, Agaricas blazei Murill is particularly rich in polysaccharides, and has shown particularly strong results in treating and preventing cancer. We believe that Agaricas blazei Murill is the ideal food for the people of today, who are exposed to a difficult living environment.
 

Carrier Immunity Mechanism of Polysaccharides, such as Beta-D-Glucan

This page courtesy of  Agaricus Blazei Murill Mushroom producer:

Y.S.Kentiku Kenkyuusyo Co, Ltd.
1-8-6 Kubota-cho, Nihama-City
Ehime-Prefecture, Japan 792
FAX 0897-37-5460
http://www.shikoku.ne.jp/ys/blazei.html
sekkei@ys.shikoku.ne.jp

More References:

  1. $50 -Dried mushrooms, packed into 20gr or 40 gr bags for the cancer patient
  2. $40 - Capsuled form: 120 capsules (one month prevention supply)
  3. $99 - Capsuled extract 10:1, 60 capsules
  4. $29 - Mixture Pau d. Arco, Ipe Roxo and Agaricus blazei Murill packed in 200 gr bags (10x 20gr little bags into the bag)
  5. $280 - Extract Agaricus 10:1 in powder form - 100gr bag
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